Ralph Hasenhuttl will be looking for a positive reaction from his team after blowing their 2-0 goal lead against United.
The Saints are eighth in the table and will fancy their chances against a Brighton team who are 16th.
Brighton however have played decent football this season and have four points from their last two matches, having won away at Aston Villa and then an impressive home draw against Liverpool.
Danny Ings could return to the Southampton squad after a knee problem and Nathan Redmond is also making progress from a hamstring injury.
Scroll down and click through to see how Ralph's men could line-up